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Saw palmetto

Saw palmetto extract is the most popular herbal preparation taken for benign prostatic hyperplasia, a common condition in older men. Early research indicated that the extract is well-tolerated and suggested "mild to moderate improvement in urinary symptoms and flow measures". Later trials of higher methodological quality indicated no difference from placebo. Questions of adequate blinding and delivery of any active ingredients remain.

Inhibition of both forms of 5-alpha-reductase with no reduction in cellular capacity to secrete prostate-specific antigen is indicated.

Other proposals for mechanisms of action include interfering with dihydrotestosterone binding to the androgen receptor, relaxing smooth muscle tissue similarly to alpha antagonist drugs, and acting as a phytoestrogen.

Limited in vitro and animal model studies suggest possible anti-tumor activity and potential for use in the treatment of cancer. These results have not been substantiated with human trials.

Saw palmetto extract has been suggested as a potential treatment for male pattern baldness.

CONSTITUENTS

Saw palmetto contains essential oil, fixed oil, sterols, polysaccharides.