SAMe (S-Adenosyl-L-methionine) USP
dietary supplement
For the treatment of liver disorders, osteoarthritis,depression
SAMe (S-Adenosyl-L-methionine)
Description
S-Adenosyl-L-methionine (SAMe) is a naturally occurring molecule distributed to virtually all body tissues and fluids. It is of fundamental importance in a number of biochemical reactions involving enzymatic transmethylation, contributing to the synthesis, activation and/or metabolism of such compounds as hormones, neurotransmitters, nucleic acids, proteins, phospholipids and certain drugs. It appears to function as a methyl donor to many neurotransmitters, proteins and lipids that may be involved in depressions.
Therapeutic use of SAMe as dietary supplements have gained in popularity, especially after the Dietary Supplement Health and Education Act was passed in 1994. This law allowed the distribution of SAMe as dietary supplement, and therefore allowed it to bypass the regulatory requirements for drugs of the Food and Drug Administration (FDA).
Multiple clinical trials indicate benefits for at least; depression, some liver conditions and osteoarthritis. Clinical trials with thousands of people for up to two years have demonstrated that SAMe is very well tolerated, much better than the medications with which it has often been compared.
Registered Index
CAS 29908-03-0 EINECS 249-946-8
Chemical name S-Adenosyl-L-methionine(SAMe)
Molecular formula C15H22N6O5S Molecular weight 398.44
Source It is produced by the fermentation of yeast.
Quality Standard
Quality Standard
Product name | SAM-e Tosylate Disulfate | SAM-e butanedisulfonate |
Appearance | White crystal powder, hygroscopic | White crystal powder, hygroscopic |
pH | 1.0~2.0 | 3.0~4.0 |
Dry content(HPLC) | ≥95.0% | ≥95.0% |
Ademetionine ion (HPLC) | 48.0%~52.0% | 49.0%~53.0% |
(S.S)isomer (HPLC) | ≥75.0% | ≥60% |
Water content | ≤2.5% | ≤2.5% |
Heavy metal content | ≤10ppm | ≤10ppm |
Total plate count | ≤100 cfu/g | ≤100 cfu/g |
Function (at least for, multiple others are known.)
Depression, especially on the field of depression SAMe is a big improvement. It appears to hold the promise to be a natural substance that helps depression.Medicine for numerous liver diseases such as liver cirrhosis, hepatitis (for liver cholestasis).Medicine for Osteoarthritis.It has the same qualities as the known medicine but without any side effects.Medicine for Migraine headaches, it reduces the pain by raising the serotonine level in the body.Medicine for Parkinson’s disease, it slows down the aging process of the brain, by protecting neurotransmitters and braincels .Medicine for ADHD (Attention Deficited Hyperactivity Disorder), tests have shown an improvement with 75% of the people who have used SAMe.Medicine for Fibromyalgia, research has shown a decrease in symptoms and improvement of mobility.
