It has been prescribed historically as an antihypertensive agent.

It has been prescribed historically as an antihypertensive agent. It has found new uses, including treatment of some types of , , , anaesthetic use, and off-label, to counter the side effects of medications such as or . It is becoming a more accepted treatment for , as well as for relief of . Clonidine is increasingly used in conjunction with stimulants to treat attention-deficit hyperactivity disorder (ADHD), for which it is administered in late afternoon or evening for sleep, and because it sometimes helps moderate ADHD-associated impulsive and oppositional behavior, and may reduce . Clonidine can be used in the treatment of . Clonidine is also a mild , and can be used as premedication before surgery or procedures.