Capecitabine
purity:99%
Cas No.:154361-50-9
professional manufacturer
high quality

Capecitabine
CAS No. [158798-73-3]
Molecular formula: C15H22FN3O6
Molecular weight: 359.35
Assay 99%

Capecitabine (INN) is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil.

Capecitabine is a relatively new chemotherapy drug which is taken in tablet form because it is well absorbed from the stomach (unlike most chemotherapy drugs which have to be given directly into the blood stream). It is inactive itself, but is converted in the liver and in tumour tissue into the active anti-cancer drug, 5-fluorouracil (5-FU). 5-FU belongs to a class of anticancer drugs called antimetabolites. These drugs form “false building blocks” in molecules inside cancer cells, like DNA, “tricking” the cell into incorporating them and leading to a consequent breakdown of cellular machinery and tumour cell death.