Secnidazole
1) CSA NO.:3366-95-8
2) Molecular formula: C7H11N3O3
3) Molecular weight: 185.18
4) Assay: 98.0% ~ 102.0%

Secnidazole

Description:

Secnidazole is structurally related to the commonly used 5-nitroimidazoles metronidazole and tinidazole. These drugs share a common spectrum of activity against anaerobic micro-organisms and they appear particularly effective in the treatment of amoebiasis, giardiasis, trichomoniasis and bacterial vaginosis. Secnidazole is rapidly and completely absorbed after oral administration and has a longer terminal elimination half-life (approximately 17 to 29 hours) than commonly used drugs in this class. in patients with intestinal amoebiasis or giardiasis, clinical or parasistological cure rates of 80 to 100% are achieved after treatment with a single dose of secnidazole 2g (30 mg/kg in children), similar to the response rates achieved with multiple dosage regimens of metronidazole or tinidazole.

Appearance: A white to pale yellow crystal or crystalline powder

Solubility: Freely soluble in Ethanol, soluble in chloroform, sparinglyoluble in water or ethyl ether,  freely soluble in dilute acid.

Ultraviolet absorbance: The absorbance (E 1cm 1%) of the solution(13ug/ml) in hydrochloride acid(9-1000) should be 331-349 at 277nm

Identification: 

     A: Chemical reaction: Matches with standard

     B: UV: Max 277 nm, min 241 nm

     C: IR: Matches with standard

Melting range: 68 to 78 °C

Clarity of Ethanol solution: 2% w/v in Ethanol should be clear

Solubility in dilute acid: 5% w/v in 1 N HC1 should be freely soluble

pH: 5.5-7.5, determined in 1% w/v solution in water

Water content (KF): ≤6.0%

Residue on ignition: ≤0.1%

Heavy metals: ≤20ppm

Related substances: 

2-methyl-5-nitronimidazole: ≤0.5%

Any other individual impurity: ≤0.5%

Total impurities: ≤1.0%

Residual solvent: 

Dichloromethane: ≤300ppm

Ethyl acetate: ≤1000ppm

Assay (on anhydrous basis): 98.0% ~ 102.0%

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