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Drugs Medecine Levofloxacin Hydrochloride
Drugs Medecine Levofloxacin Hydrochloride

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Quality/Safety Certification: 0.00


1.Best quality and most competitive price
2.Samples:free
3.GMP and DMF certificate;...
4.Packing: 25kg/drum

Specification:

 

Levofloxacin

CAS No.:  100986-85-4 

Olecular formula :   C18H20FN3O4·1/2H2O
Molecualr weight:  370.36

 

Properties:

This product is white or light yellow crystalline powder; odorless, bitter taste. This product is dissolved in water, slightly soluble in methanol, slightly soluble in ethanol, slightly soluble in ethanol, almost insoluble in chloroform.

 

Pharmacology actions:

The antibacterial activity of levofloxacin is about twice that of ofloxacin, and its main mechanism is inhibiting bacterial DNA gyrase (bacterial topoisomerase ) activity, stoping bacterial DNA replication.

Levofloxacin is a broad spectrum antimicrobial activity. It have a strong antibacterial activity for the majority of Enterobacteriaceae, such as Escherichia coli, Klebsiella spp, Serratia, Proteus, Shigella, Salmonella , Citrobacter, Acinetobacter, Pseudomonas, Haemophilus influenzae, Neisseria gonorrhoeae and other Gram-negative bacteria.

 

 COA (CP2010)

ITEMS

SPECIFICATION

RESULT

APPEARANCE

OFF-WHITE OR LIGHT-YELLOW CRYSTALLINE POWDER

LIGHT-YELLOW

CRYSTALLINE POWDER

SPECIFIC ROTATION

BETWEEN –92°AND -99°

-95.3°

 

 

IDENTIFICATION

 

HPLC

CORRESPONDS TO THE RETENTION TIME OF MAIN PEAK IN THE CHROMATOGRAM OBTAINED FROM THE REFERENCE SOLUTION

 

MEET THE REQUIREMENTS

IR

CORRESPONDS TO THE IR SPECTRUM OF LEVOFLOXACIN RS

MEET THE REQUIREMENTS

CLARITY OF SOLUTION

THE SOLUTION SHOULD BE CLEAR

CLEAR

APPERANCE

THE ABSORBANCE AT 450nm IS NOT MORE THAN 0.1

0.05

DEXTROISOMER

NOT MORE THAN 1.0%

0.3%

TOTAL IMPURITIES

NOT MORE THAN 0.50%

0.10%

ANY OTHER INDIVIDUAL IMPURITY

NOT MORE THAN 0.25%

0.07%

WATER

BETWEEN 2.0%AND 3.0%

2.5%

RESIDUE ON IGNITION

NOT MORE THAN 0.1%

0.06%

HEAVY METALS

≤10PPM

<10PPM

ASSAY (ON THE DRIED BASIS)

NOT LESS THAN 98.5%

99.5%

Conclusion

The product meets the requirements of CP2010

 

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