Product Name:

Topotecan Hydrochloride

Appearance :

yellow white crystalline powder

Cas:

119413-54-6

Molecular formula:

C23H23N3O5

Molecular weight :

421.4458

Supplier name:          

xi’an lyphar biotech co.,ltd

Synonyms:

(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride; Nogitecan hydrochloride; Hycamtin; Topotecan HCl; (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride (1:1); (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Specification

99%

Structure

Function

1 Topotecan Hydrochloride (Topotecan HCl) is a semi-synthetic derivative of camptothecin. Camptothecin is a natural product extracted from the bark of the tree Camptotheca acuminata. Topoisomerase-I is a nuclear enzyme that relieves torsional strain in DNA by opening single strand breaks. Once topoisomerase-I creates a single strand break, the DNA can rotate in front of the advancing replication fork. Topotecan intercalates between DNA bases. This intercalation disrupts the DNA deplication machinery when it reaches a site where topotecan is intercalated.

2  Topotecan is an antineoplastic agent used to treat small cell lung cancer, and certain cancers of the ovary.

3 Topotecan is also used to treat relapse of small cell lung cancer that initially responded to other drugs. Increases in survival times have been observed in patients treated with topotecan compared to control populations treated with paclitaxel.

Deliver time:

Within 2 days

Package

Sealed export grade drum & double of sealed plastic bag

Storage

Store in cool & dry place not freeze., keep away from strong light and heat

Xi’an Lyphar Biotech Co., Ltd. was founded in 2001, and located in Hi-Tech Industrial Zone, Xi’an City, Shannxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in both plant extract and high technology chemicals area.

Lyphar Biotech is specialized in Plant Growing, Research, Production, Process and Sales. It has absolute advantage because of strong research strength, modern management system and high-quality marketing team.

There are 15 experts in our research team. We insist in innovation and produce high quality products. And we have GMP standard workshop and complete stainless extraction equipment. The superior product quality is guaranteed by 300,000 level air-conditioning clear system within purification, drying and packing procedures. We have 2 sales departments over 30 people and sell our products all over the world.