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Grape seed extract 95% Proanthocyanidin and polyphenols
Grape seed extract 95% Proanthocyanidin and polyphenols

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1.We are the first supplier of grape seed extract in China.
2.high orac 1800umol
3.95% Proanthocyanidin
4.Polyphenols 90%

  Our Advantage on this product:

 

1.We are the first supplier of grape seed extract in China.
2.high orac 1800umol (Microencasulation technology offered for this product)
3.95% Proanthocyanidin
4.Polyphenols 90%

 

Our brief specs are as follows:

Product Name/ Active Ingredient   Pharmacopoeia/Certificate   Package (kg)   Product code         Main applications

Grape Seed Extract

Proanthocyanidins≥95% (Bate-Smith)

Powder

USP,FCC,Ph. EUR., GMP

5

25

GS1021

Used in dietary supplements.

 

High ORAC≥18000umol TE/g

Powder

USP,FCC,Ph. EUR., GMP,

 

5

25

GS1022

Polyphenols ≥90%(Folin-C )

Powder

USP,FCC,Ph. EUR., GMP,

 

5

25

GS1022

High ORAC≥18000umol TE/g

Microencapsulated powder

USP,FCC,Ph. EUR., GMP,

 

1

5

25

GS3021

 

 

1. Background

Proanthocyanidins, also known as condensed tannins, are a class of biologically active flavonoids that has been called

"super antioxidants". Typically concentrated in the bark of trees and in the outer shells of seeds, proanthocyanidins serve

to protect plants against oxidative elements such as oxygen and sunshine. Grape seeds are a particularly rich source of

proanthocyanidins.
Grape seed extract, concentrated from the seeds of grape (Vitis vinifera L.), has a high content of compounds known as

oligomeric proanthocyanidins (OPCs), which are made up of proanthocyanidin monomers.

 

2. Functional components of Grape Seed Extract
Grape seed extract is made up of one kind of polyphenol compounds including gallic acid, catechin, epicatechin, catechin

-3-gallate, epicatechin-3-gallate and proanthocyanidins, The majority of which are proanthocyanidins, which account for the

most dominant among the effective components.
Proanthocyanidins are polyphenol compounds condensed through the link models of C4→C8 or C4→C6 bond by monomers of (+)

-catechin, (-)-epicatechin, (-)-epicatechin-3-gallate etc.. According to the difference of polymerization degree,

proanthocyanidins are also sorted into oligomeric proathocyanidin (OPC) and polymeric proathocyanidin (PPC). Commonly,

Proanthocyanidins with 2-7 polymerization degree was named OPC, bioactivity and water-solubility of which are the best.

 


Figure 2 the chemical structures of main functional components in Grape Seed Extract


3. Function of Grape Seed Extract

According to the free radical theory of aging, free radicals are a primary cause of many degenerative diseases and

accelerated aging. Consequently, antioxidant and/or free radicals scavengers may retard the aging process. Dr Winter has

discovered that regular consumption of ginkgo may extend both the average and the maximum life span in rats.8 Likewise, it

has been reported recently that long-term supplementation with melatonin as antioxidant has a life-extending effect on

Drosophila melanogaster.9 It would be interesting to repeat such study using grape seed extract since it is best known as a

powerful antioxidant to scavenge free radicals.
As shown in Figure 4, BannerBio Grape Seed Extract, when added daily to the nutrition medium at appropriate

concentrations [0.03%, 0.08% in the diet (w/w), Group I and II], significantly increased the life span of Drosophila

melanogaster (Oregon wild strain) regardless of sex.10 In the case of the concentration of 0.08% (Group II), the percentage

increase in the BannerBio ?Grape Seed Extract fed female flies was 20% in median life span, 12% in maximum life span and 12%

in average life span relative to the controls. Similar results were also observed in the experiments of the 200 male flies .

 


Figure 4  Effects of BannerBio ?Grape Seed Extract on the Life Span of Drosophila melanogaster

 

4. Stability of Grape Seed Extract

No loss of potency was found after 3 months of storage at the temperature of 37~40 oC and relative humility of 75%,10

indicating BannerBio ?Grape Seed Extract is extremely stable on the shelf. The product is also very soluble in water

(insoluble substances < 1% when 1 g/100ml).

 

5. Nutrition analysis

 

 

  

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