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St. John's Wort contains hypericin that inhibits monoamine oxidase, a bodily chemical associated with depression. It appears that hypericin does not act alone. Like many herbal medicines, St. John's Wort relies on the complex interplay of many constituents for its antidepressant actions. Patients suffering from depression received relief, increased appetite, more interest in life, greater self-esteem and restoration of normal sleeping patterns.

St. John's Wort is available as tea, tincture, decoction, oil, and in capsule form. Teas should be made with 1-2 cups of flowers per 1 cup of boiling water. This tea can be drunk three times daily. The dosage of the tincture is 1/4 to 1 teaspoon up to three times daily.