... system. The most serious adverse effect associated with chloramphenicol treatment is bone marrow toxicity, which may occur in two ... toxic effect of the drug and is usually reversible, and aplastic anemia, which is idiosyncratic (rare, unpredictable, and unrelated to ... any of the cephalosporins), chloramphenicol remains the first-choice treatment for staphylococcal brain abscesses. It is also useful in ...