L-leucine:
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Leucine is utilized in the liver, adipose tissue, and muscle tissue. In adipose and muscle tissue, leucine is used in the formation of sterols, and the combined usage of leucine in these two tissues is seven times greater than its use in the liver.

Leucine is the only dietary protein that has the capacity to stimulate muscle protein synthesis. As a dietary supplement, leucine has been found to slow the degradation of muscle tissue by increasing the synthesis of muscle proteins in aged rats.

Leucine toxicity, as seen in decompensated Maple Syrup Urine Disease (MSUD), causes delirium and neurologic compromise, and can be life-threatening.